LHONcellline

由 S Beretta 著作 · 2004 · 被引用 144 次 — Leber hereditary optic neuropathy (LHON) is a maternally inherited form of retinal ganglion cell degeneration leading to optic atrophy which is caused by point ...

由 J Wang 著作 · 2023 — Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA.

由 A Ghelli 著作 · 2003 · 被引用 215 次 — We here report that osteosarcoma-derived cytoplasmic hybrids (cybrid) cell lines harboring one of the three most frequent LHON pathogenic mutations, at ...

Cell line name, LHON1-hiPSC5. Synonyms, LHON.1.H.iPSC.5; LHON-hiPSC5; RIi014-A. Accession, CVCL_C883. Resource Identification Initiative, To cite this cell ...

由 C Peron 著作 · 2021 · 被引用 9 次 — LHON cell lines reprogramming efficiency. (A) Number of hiPSC clones ... Differentiation of human ESCs to retinal ganglion cells using a CRISPR ...

由 M Baglivo 著作 · 2023 · 被引用 1 次 — The in-depth evaluation of cellular respiration in fibroblasts is a good approach to evaluating novel mtDNA variants associated with LHON but needs further ...

由 P Jiang 著作 · 2016 · 被引用 39 次 — Leber's hereditary optic neuropathy (LHON) is the most common mitochondrial disease. Mitochondrial modifiers are proposed to modify the phenotypic ...

由 C Peron 著作 · 2020 · 被引用 13 次 — LHON is characterized by the selective degeneration of the retinal ganglion cells (RGC). Almost all LHON maternal lineages are homoplasmic mutant (100% mtDNA ...

由 D Ji 著作 · 2022 · 被引用 1 次 — LHON is a disorder characterized by severe and rapidly progressing visual loss caused by a mutation in the mitochondrial gene encoding NADH, leading to the ...